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BEGIN:VEVENT
DTSTAMP:20260608T050201Z
DTSTART;VALUE=DATE-TIME:20260617T141500
DTEND;VALUE=DATE-TIME:20260617T151500
SUMMARY:BMS Seminar: Watching life unfold\, one cell at a time: from germ
  cell migration to ventral folding in the post-implantation mouse embryo
 \, Dr Kate McDole\, MRC Laboratory of Molecular Biology\, University of 
 Cambridge
TZID:Europe/London
UID:20260617-8ac672c69a9158c4019aa104a0963e0a@warwick.ac.uk
CREATED:20260604T104921Z
DESCRIPTION:Abstract: o How does a uniform population of cells transform 
 into a beating heart\, a gut\, a brain? The cellular and mechanical proc
 esses driving early mammalian organ formation remain poorly understood\,
  largely because mammalian embryos are incredibly sensitive to imaging a
 nd culture. We have developed an adaptive light-sheet microscope purpose
 -built for the requirements of the post-implantation mouse embryo\, enab
 ling single-cell resolution imaging across days of development. Paired w
 ith computational tools for cell tracking\, fate mapping\, and 3D recons
 truction\, this platform lets us observe morphogenesis in real time\, ac
 ross the whole embryo. We first applied this system to the journey of pr
 imordial germ cells (PGCs)\, founders of the germline that must navigate
  rapidly changing tissue environments as the embryo reorganizes around t
 hem. We reveal that PGCs migrate heterogeneously\, dynamically adapting 
 their behaviour to the distinct extra-cellular matrix compositions and p
 hysical landscapes they encounter. We then focus on ventral folding and 
 foregut formation. Through live imaging and computational reconstruction
  of the folding process\, we uncover striking and previously undescribed
  cellular behaviours\, revealing the precise choreography driving one of
  the embryo's earliest organogenesis events. Biography: o Kate McDole is
  a Group Leader at the MRC Laboratory of Molecular Biology in Cambridge\
 , UK. Her lab explores the morphogenesis of the early mouse embryo using
  a combination of advanced light-sheet microscopy\, biology\, computatio
 nal methods and biophysics. Kate did her PhD at Johns Hopkins at the Car
 negie Institute for Science’s Department of Embryology in the lab of Yix
 ian Zheng\, using two-photon microscopy to study early cell fate establi
 shment in the pre-implantation mouse embryo. She moved to HHMI’s Janelia
  Research Campus to do her post-doc in the lab of Philipp Keller\, devel
 oping a light-sheet microscope for imaging post-implantation mouse devel
 opment.
LOCATION:IBRB Lecture Theatre\, Gibbet Hill Campus
CATEGORIES:BiomedicalSciences,Directorate Seminars
LAST-MODIFIED:20260604T104921Z
ORGANIZER;CN=Jas Bains:
END:VEVENT
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