ࡱ> C bjbj hh, J J @dDt^K K K $DpC]K ) "K K K C[$$$K $K $$_tK|'ڷ`Y"p?wF 0wj"jK|K|j|4 K K $K K K K K CC{#K K K K K K K jK K K K K K K K K J X : Robert J. Mishur  HYPERLINK "mailto:rjmishur@widener.edu" rjmishur@widener.edu / (610) 499-1080  EDUCATION 2008 Ph.D. in Chemistry, Northern Illinois University, Dekalb, IL Specialization: Inorganic Chemistry Dissertation: Synthesis, Characterization, Redox Kinetics, and Assessment of DNA and Thiol Binding of a New Class of Platinum(II) and (IV) Pyrophosphato Complexes (Mentor Dr. Rathindra Bose) 2002 B.S. in Chemistry, University of Illinois, Urbana, IL Minor in mathematics Thesis: Surface Interactions of K8[-SiW11O39] and Na2H[-PMo12O40] with Silver and Gold Electrodes (Mentor Dr. Andrew Gewirth) INSTRUCTIONAL EXPERIENCE Widener University, Chester, PA Assistant Professor of Chemistry August 2022  Present Assistant Teaching Professor of Chemistry August 2016 May 2022 Courses Taught CHEM 106 GOB* Lab CHEM 145 General Chemistry I CHEM 146 General Chemistry II CHEM 147 General Chemistry I Lab CHEM 148 General Chemistry II Lab CHEM 255 Organic Chemistry I CHEM 257 Organic Chemistry I Lab CHEM 258 Organic Chemistry II Lab CHEM 375 Inorganic Chemistry CHEM 390 Chemical Literature *general chemistry, organic chemistry, and biochemistry lab for nursing majors Service Science Division representative to the College of Arts & Sciences Committee on Diversity, Equity, and Inclusion 2022-2024 Chair, general chemistry subcommittee to revise curriculum for life science majors, FA 2021-SP 2022 Judge, Summer Undergraduate Research and Creative Activities Symposium, 2017, 2018, 2021, 2022 Member of search committee for visiting assistant teaching professor, 2021 Chemical hygiene officer for the Department of Chemistry, 2019-present Chair, Science Division Safety Committee, 2018-present Served on ad hoc merit committee, 2019 Freshman general education advisor 2017-2018 Member of search committee for tenure-track physical chemist, 2018 Search Committee for Visiting Senior Lecturer in Chemistry, 2017 Member of search committee for visiting physical chemist, 2016 Member, Science Division Safety Committee, 2016 Manor College, Jenkintown, PA Professor of Chemistry and Chemistry Lab Coordinator August 2015 May 2016 Courses Taught Fundamentals of Chemistry I (lecture + lab) Fundamentals of Chemistry II (lecture + lab) Organic Chemistry I (lecture + lab) Organic Chemistry II (lecture + lab) Additional Responsibilities and Service Academic advising Member of the library committee Responsibilities as lab coordinator included overseeing hazardous waste disposal, routine testing and maintenance of lab safety equipment, and maintaining the chemical inventory and SDS database. Delaware Valley University, Doylestown, PA Adjunct Instructor in Chemistry January 2015 August 2015 General Chemistry II Lab Organic Chemistry II Organic Chemistry II Lab Biochemistry Lecture Richard Stockton University, Galloway, NJ Visiting Assistant Professor of Chemistry September 2014 June 2015 Chemistry I: General Principles Chemistry I Lab Chemistry II Lab (first semester organic) Adjunct Instructor in Chemistry, St. Philips College, San Antonio, TX January 2013 August 2014 Introductory Chemistry (GOB) Laboratory II General Chemistry I Lecture and Lab Adjunct Instructor in Chemistry, University of the Incarnate Word, San Antonio, TX August 2013 May 2014 General Chemistry Laboratory Chemical Principles I Chemical Principles II Organic Chemistry I Lab Organic Chemistry II Lab Adjunct Instructor, St. Marys University, San Antonio, TX August 2013 May 2014 Organic Chemistry I Lab Organic Chemistry II Lab Graduate Teaching Assistant, Northern Illinois University, Dekalb, IL August 2003 August 2008 Introductory Chemistry Lab Organic Chemistry I Lab Inorganic Chemistry Lab Physical Chemistry I Lab RESEARCH EXPERIENCE Current Research Project: Synthesis and anticancer properties of monodentate Pt(II)-pyrophosphato complexes Post-Doctoral Fellow, University of Texas Health Science Center, San Antonio, TX September 2010 - May 2013 (Mentor: Shane Rea) Post-Doctoral Fellow, Tulane University, New Orleans, LA August 2008 September 2010 (Mentor: Janarthanan Jayawickramarajah) Research Expertise Inorganic and organic synthesis, microscale synthesis, microwave synthesis, green chemistry NMR techniques, including: 1H NMR, 31P NMR, 195Pt NMR, COSY, NOESY, water suppression (Watergate, Wet), variable temperature NMR. Experienced with changing NMR probe heads, operating auto-sampler, tuning and shimming (manual and automatic). HPLC purification on analytical and semi-prep scales Preparation of samples for metabolomics analysis and processing of high-dimensional GC-MS data Cell culture and cell assays (colorimetric, clonogenic) Use of modern laboratory instrumentation including UV-Vis and fluorescence spectrometers, MALDI-TOF, FTIR, and GC-MS DNA and RNA extraction and isolation, gel electrophoresis, protein quantification assays, Western blot, PCR Prior work with C. elegans FUNDING 2023-2024 Widener University Provost Grant Exploration of the Properties of a Class of Novel Monodentate Platinum(II)-Pyrophosphate Complexes 2023-2024 Faculty Development Grant (Widener University) - Development of Next-Generation Anticancer Platinum Complexes 2022 Widener University Provost Grant Synthesis of PD-1/PD-L1 Inhibitors as a Therapeutic Strategy for Tumor Immunotherapy ADDITIONAL WORK EXPERIENCE Quality Assurance Technician, Cabot Microelectronics, Aurora, IL November 2002 August 2003 Quality Assurance Technician, Guardian West, Urbana, IL June 2001 April 2002 ADDITIONAL TRAINING Drexel CASTLE POGIL Workshop, Drexel University, Philadelphia, PA (2018) Cooperative Learning Workshop, University of the Incarnate Word, San Antonio, TX (2013) American Chemical Society Leadership Institute, Dallas, TX (2013) 5th Annual Isotope Tracers in Metabolic Research Course: Principles and Practice of Kinetic Analysis, Little Rock, AR (2012) CERTIFICATIONS Chemical Hygiene Officer National Registry of Certified Chemists (2019) PROFESSIONAL MEMBERSHIPS AND APPOINTMENTS 2022 Present Member, Alpha Chi Sigma 2006 Present Member, American Chemical Society 2023 American Chemical Society Middle Atlantic Regional Meeting Awards Committee 2022-2025 Director, American Chemical Society, Delaware Section (Elected) 2021-2023 Regional Meetings Committee, ACS Division of Chemical Education 2021 Interim Director, American Chemical Society, Delaware Section 2020-2022 Alternate Councilor, American Chemical Society, Delaware Section 2019 Chair, American Chemical Society, Delaware Section 2015 2016 Co-chair, Younger Chemists Committee, Philadelphia Section 2014 Chair, American Chemical Society, San Antonio Section 2013 Chair-Elect and Program Chair, American Chemical Society, San Antonio Section AWARDS AND HONORS 2017 Joint Runner-Up Best Paper Prize, Aging Cell (Mitochondrial Metabolites Extend Lifespan) 2012 Recipient of Joe H. Ward, Jr. and Betty B. Ward Award for Post-doctoral Excellence in the Study of Biology of Aging 2011 Selected for Institutional National Research Service Award to study Aging, University of Texas Health Science Center at San Antonio 2008 Selected for Institutional National Research Service Award to study Pulmonary Diseases, Tulane University 2008 Second place, Fifth Annual Sigma Xi Graduate Student Research Competition, Northern Illinois University 2004 Nominated for Graduate Fellowship Award by the Department of Chemistry and Biochemistry at Northern Illinois University PEER-REVIEWED PUBLICATIONS Mishur, R. J.; Khan, M.; Munkcsy, E.; Sharma, L.; Bokov, A.; Beam, H.; Radetskaya, O.; Borror, M.; Lane, R.; Bai, Y.; Rea, S. L. Mitochondrial Metabolites Extend Lifespan. Aging Cell, 2016, 15, 336-348. Shim, E.-H.; Livi, C.; Knight, J.; Holmes, R.; Rakheja, D.; Velu, S.; Dutta, S.; Chenna, B.; Rea, S.; Mishur, R.; Li, Q.; Bae, S.; Block, K.; Sudarshan, S. L-2-Hydroxyglutarate: An Epigenetic Modifier and Putative Oncometabolite in Renal Cancer. Cancer Discov., 2014, 4(11), 1290-8. Mishur, R. J., Butler, J. A., & Rea, S. L. Exometabolomic Mapping of Caenorhabditis elegans A Tool to Non-Invasively Investigate Aging. Biological Aging: Methods and Protocols, Second Edition, 2013. Butler, J. A., Mishur, R. J., Bhaskaran, S., & Rea, S. L. A Metabolic Signature for Long Life in the C. elegans Mit Mutants. Aging Cell, 2013, 12, 130-138. Butler, J. A.*, Mishur, R. J.*, Bokov, A. F., Hakala, K. W., Weintraub, S. T., & Rea, S. L. Using GC-MS Metabolomics to Profile the Anaerobic Response of C. elegans. PLoS One, 2012, 7(9), no pp. *Both authors contributed equally to this work Mishur, R. J. and Rea, S. L. Applications of Mass Spectrometry to Metabolomics and Metabonomics: Detection of Biomarkers of Aging and of Age-Related Diseases. Mass Spectrom. Rev., 2012, 31(1), 70-95. Mishur, R. J.; Griffin, M. E.; Battle, C. H.; Shan, B.; Jayawickramarajah, J. Molecular Recognition and Enhancement of Bioactivity of CD437 by -Cyclodextrin. Bioorg. Med. Chem. Let., 2011, 21(2), 857-860. Bose, R. N.; Maurmann, L.; Mishur, R. J.; Yasui, L.; Gupta, S.; Grayburn, S.; Hofstetter, H.; Salley, T. Non-DNA Binding Platinum Anticancer Agents: Cytotoxic Activities of Platinum-Phosphato Complexes Toward Human Ovarian Cancer Cells. Proc. Nat. Acad. Sci. U.S.A., 2008, 105(47), 18314-18319. Mishur, R. J.; Zheng, C.; Gilbert, T. M.; Bose, R. N. Synthesis, X-ray Crystallographic and NMR Characterizations of Platinum(II)- and Platinum(IV)- Pyrophosphato Complexes. Inorg. Chem., 2008, 47(18), 7972-7982. PATENTS Bose, R. N.; Mishur, R. J.; Yasui, L.; Gupta, S.; Maurmann, L., Monomeric Phosphoplatins as Anticancer Drugs, U. S. Patent and Trademark Office, 2007, Provisional Application 60/954,126. CONFERENCE PRESENTATIONS Mishur, R. J.; Butler, J. A.; Rea, S. L. A Unique Metabolism Links the Long-Lived Mit Mutants of C. elegans Oral presentation, World Aging Online Symposium, November 28, 2012. Mishur, R. J.; Judkins, J. C.; Butler, J. A.; Mahanti, P.; Schroeder, F. C.; Rea, S. L. Examination of possible signaling pathways which lead to longevity modulation in C. elegans Poster presentation, The 2012 San Antonio Nathan Shock Institute Conference on Aging, Bandera, TX, October 19, 2012. Mishur, R. J.; Butler, J. A.; Rea, S. L. Exometabolomic Mapping Unifies the Long-Lived Mit Mutants of C. Elegans Poster presentation, American Chemical Society 244th National Meeting, Philadelphia, PA, August 21, 2012. Mishur, R. J.; Butler, J. A.; Bokov, A. F.; Weintraub, S. T.; Rea, S. L. Metabolic Footprinting of the C. elegans Exometabolome via GC-MS Poster presentation, American Chemical Society 67th Southwest Regional Meeting, Austin, TX, November 9, 2011. Mishur, R. J.; Griffin, M. E.; Shan, B.; Jayawickramarajah, J.  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Mishur, R. J.; Bose, R. N. Platinum Phosphato Complexes: How They Might Work as Anticancer Agents Poster presentation, American Chemical Society 233rd National Meeting, Chicago, IL, March 27, 2007. Mishur, R. J.; Bose, R. N. 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